Citizens Petition
- Sustaining Partners
May 2012-
The Search for an Ideal Analgesic
June 2011-
Pharmacotherapy for Prescription Opioid Addiction
March 2011-
Advancing Safe Opioid Prescribing through Prescriber Training and Behavior Change
June 2010-
Payer Issues Related to Prescription Opioid Monitoring and Abuse
March 2010-
The role of Dentists in Preventing Opioid Abuse
July 2009-
Risk Evaluation and Mitigation Strategy for Prescription Opioids
April 2009-
Prescription Monitoring Research Update
November 2008-
Co-ingestion of Alcohol with Prescription Opioids
June 2008-
The Role of Urine Drug Monitoring in Pain Management
March 2008-
Sources of Diverted Prescription Opioids
September 2007-
Understanding the Types of Opioid Abusers
March 2007-
Responding to Signals of Opioid Abuse
November 2006-
Development of Abuse Deterrent Formulations
September 2006-
Best Practices in Opioid Risk Management
October 2005-
Opioid Abuse Resistance
March 2005-
Opioid Risk Management

Tufts Health Care Institute Program on
Opioid Risk Management

The mission of the Tufts Health Care Institute Program on Opioid Risk Management is to address challenges in the development and utilization of opioid analgesics, by engaging a multidisciplinary group of stakeholders focused on optimizing the benefits of opioid for pain management, and minimizing their risks, including abuse and diversion.

July 23 & 24, 2009


Executive Summary

July 2009

Risk Evaluation and Mitigation Strategy for Prescription Opioids: An In-Depth Review of Fundamental Issues
Nathaniel Katz, MD, MS Presentation >>

Opening Remarks
Michael Klein, Ph.D. Presentation >>

How Industry Uses Root Causes Analysis to Manage Risk and Linkage to REMS Intervention
John Carroll, PhD Presentation >>

What is the Public Health Rationale for Prescription Opioid REMS to Addressing Public Health Concerns
John Brownstein, PhD Presentation >>

The REMS Experience: Update and Review
Edgar Adams, ScD Executive Director, Epidemiology Presentation >>

Practitioner Education: What are the Core Elements of Safe Opioid Prescribing?
Lynn Webster, MD Presentation >>

Practitioner Education: What Forms of Training and Feedback will Change Practitioner Behavior?
Thomas Kosten, MD Presentation >>

Patient Education: What Do We Want Patients Do with their Opioids?
Seddon Savage, MS, MD Presentation >>

Patient Education: What Methods do Practitioners Use to Train Patients to Respect Opioids?
Will Rowe Presentation >>

Unintended Consequences: Potential Patient Barriers to Accessing Prescription Opioids Because of REMS
Richard Payne, MD, PhD Presentation >>

Retail Pharmacy REMS for Opioids; Challenges and Solutions
Roger Pinsonneault, RPh Presentation >>

Distribution of Controlled Substances in the US: A Primer
Anita Ducca, MS Presentation >>

How Do We Evaluate the Effectiveness of REMS: Core Requirements
Nabarun Dasgupta, MPH Presentation >>

Concurrent Workgroup Breakouts

Breakout Group 1: Practitioners
What desired practitioner behaviors do we want?
What is safe-opioid prescribing behavior?
What are the key elements of safe practice?
Develop a checklist that physicians can use
on a systematic basis with patients.
Presentation >>

Breakout Group 2: Patients:
What are the patient behaviors that we want to decrease abuse?
What do we want patients to do?
How do we know if they are following suggestions?
Develop a checklist that patients can receive and implement to reduce abuse, accidental ingestion, or access.
Presentation >>

Breakout Group 3: Pharmacists' Behavior:
Presentation >>

Breakout Group 3: Standards for Evaluation of REMS Programs:
Presentation >>

2008 Tufts Health Care Institute •   Boston, MA 02111 •   (617) 636-1000